Peptide delivery
Peptides are very suitable for targeting intracellular protein-protein interactions but have poor cell permeability. Conjugating MNM to peptides or small proteins can potentially lead to effective interactions with their intracellular target. We have shown in a POC study that an MNM-peptide led to an improved intracellular activity as compared to a CPP-peptide. Moreover, MNM conjugation to this peptide in addition to the CPP unit resulted in a ~20-fold enhanced intracellular activity indicating a synergistic effect.
